The multi-award-winning drama enters a new decade, the 1970s. This brings with it new challenges for both Nonnatus House and British society as a whole. The Seventies start as they mean to go on, with Nonnatus House plunged into disarray when activists staging a bid for independence blockade access to the Isle of Dogs. Amid the poverty and uncertainty of life in a declining Docklands, the midwives must also face cases of manic depression, gonorrhoea, spina bifida, abortion - and an apparently immaculate conception.